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Sibutramine Hydrochloride Monohydrate
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Brand Name(s):Meridia Drug Class:Inhibitor of neurotransmitter reuptake Available OTC?:NoAvailable Generic?:No | |
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Available InCapsules Why PrescribedTo aid in the medical management of obesity in conjunction with a carefully supervised diet and exercise program. The drug is only recommended for overweight people with a body mass index (BMI) greater than 30 or greater than 27 in people with other risk factors such as diabetes or high blood pressure. How It WorksSibutramine affects the appetite control center in the brain by inhibiting the reuptake of neurotransmitters like serotonin. The resulting increase in their availability suppresses appetite. Range and FrequencyTo start, 10 mg once a day. Dose may be increased up to 15 mg once a day. Onset of EffectSignificant weight changes may take several weeks or months to develop. Duration of ActionWhen taking sibutramine regularly, most people lose weight within the first six months. Weight loss is maintained for the duration of therapy. Dietary AdviceCan be taken with a meal or on an empty stomach. StorageStore in a tightly sealed container away from heat, moisture, and direct light. Missed DoseIf you miss a dose one day, do not double the dose the next day. Resume your regular dosage schedule. Stopping the DrugThe decision to stop taking the drug should be made in consultation with your physician. Prolonged UseThe safety and effectiveness of sibutramine have not been determined beyond 1 year of use. Over 60No specific studies have been done on older patients. Driving and Hazardous WorkDo not drive or engage in hazardous work until you determine how the medicine affects you. AlcoholSibutramine may increase the sedative effects of alcohol. Consult you doctor for specific advice. PregnancySibutramine should not be used by pregnant women. Before taking sibutramine, tell your doctor if you are pregnant or plan to become pregnant. Breast FeedingSibutramine should not be used by nursing mothers. Infants and ChildrenChildren under the age of 16 should not use sibutramine. Special ConcernsAlthough no serious adverse reactions have been reported with sibutramine (at the time of publication), other diet drugs have been associated with an increased risk of potentially grave cardiovascular and cardiopulmonary problems. If you experience any unusual or disturbing adverse effects, stop taking sibutramine and call your physician immediately. Overdose SymptomsNo cases of overdose have been reported. What to DoIf someone takes a much larger dose than prescribed or a child swallows the drug, call your doctor, emergency medical services (EMS), or the nearest poison control center immediately. Drug InteractionsYou should not take sibutramine if you take MAO inhibitors, other weight loss medications, medications for depression, migraine medications, dihydroergotamine, meperidine, fentanyl, pentazocine, dextromethorphan (found in many cough medicines), lithium, or tryptophan. Sibutramine may interact with ketoconazole, erythromycin, over-the-counter cough and cold medications, allergy medicines, and decongestants. Consult your doctor for specific advice. Food InteractionsNo known food interactions. Disease InteractionsYou should not take sibutramine if you have coronary artery disease, angina, cardiac arrhythmia, history of heart attack, congestive heart failure, history of stroke, anorexia nervosa, history of seizures, or narrow angle glaucoma. Sibutramine can substantially raise blood pressure in some patients. Use of sibutramine may cause complications in patients with liver or kidney disease, since these organs work together to remove the medication from the body. Consult your doctor if you have a history of migraines, mental depression, Parkinson's disease, thyroid disorders, osteoporosis, gallbladder disease, a major eating disorder (anorexia nervosa or bulimia nervosa), or any other medical problem. Serious Side EffectsNo serious side effects have yet been reported. However, if you experience symptoms such as shortness of breath or chest pain that were not present before taking the medication, call your doctor. Common Side EffectsDry mouth, constipation, insomnia. Less Common Side EffectsHeadache, increased sweating, increased blood pressure and heart rate. | |
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