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Norfloxacin

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Norfloxacin

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In this Article:

Brand Name(s):


Chibroxin, Noroxin

Drug Class:


Fluoroquinolone antibiotic

Available OTC?:

No

Available Generic?:

No

  • Available In
  • Why Prescribed
  • How It Works
  • Range and Frequency
  • Onset of Effect
  • Duration of Action
  • Dietary Advice
  • Storage
  • Missed Dose
  • Stopping the Drug
  • Prolonged Use
  • Over 60
  • Driving and Hazardous Work
  • Alcohol
  • Pregnancy
  • Breast Feeding
  • Infants and Children
  • Special Concerns
  • Overdose Symptoms
  • What to Do
  • Drug Interactions
  • Food Interactions
  • Disease Interactions

  • Noroxin 400 mg
    (Merck)
  • Serious Side Effects
  • Common Side Effects
  • Less Common Side Effects

    Available In


    Eye drops, tablets

    Why Prescribed


    To treat urinary tract infections, sexually transmitted diseases, or eye infections caused by bacteria.

    How It Works


    Norfloxacin inhibits the activity of a bacterial enzyme (gyrase) that is necessary for proper DNA formation and replication. This prevents bacteria cells from reproducing.

    Range and Frequency


    For urinary tract infections: Adults: 400 mg, 2 times a day, for 3 to 21 days. For sexually transmitted diseases: 800 mg in a single one-time dose. For eye infections: 1 drop in each affected eye, 4 times a day, for 7 days.

    Onset of Effect


    Varies depending on the infection being treated.

    Duration of Action


    Unknown.

    Dietary Advice


    Tablets should be taken on an empty stomach, 1 hour before or 2 hours after meals, with a full glass of water. Drink plenty of fluids, especially citrus juices or cranberry juice, but avoid milk and dairy derivatives.

    Storage


    Store in a tightly sealed container away from heat, moisture, and direct light.

    Missed Dose


    Take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

    Stopping the Drug


    It is very important to take this drug as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy.

    Prolonged Use


    If your symptoms do not improve or instead become worse after a few days, consult your doctor promptly.

    Over 60


    No special problems are expected.

    Driving and Hazardous Work


    Do not drive or engage in hazardous work until you determine how the medicine affects you.

    Alcohol


    It is advisable to abstain from alcohol when fighting an infection.

    Pregnancy


    In some animal tests, norfloxacin has caused birth defects. Adequate studies in humans have not been done. It should be used during pregnancy only if potential benefits clearly justify the risks. Before you take norfloxacin, tell your doctor if you are pregnant or plan to become pregnant.

    Breast Feeding


    Norfloxacin passes into breast milk and may cause serious side effects in the nursing infant; use of the drug is discouraged when nursing.

    Infants and Children


    Oral forms of fluoroquino-lones such as norfloxacin should not be used by persons under the age of 18. Norfloxacin eye drops should not be used by children under 1 year old.

    Special Concerns


    If norfloxacin makes your skin or eyes more sensitive to sunlight, wear sunglasses and protective clothing, use a sunscreen with an SPF (sun protection factor) of 15 or higher, and avoid excessive exposure to the sun.

    Overdose Symptoms


    Nausea, headache, dizziness, vomiting, drowsiness, seizures.

    What to Do


    Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

    Drug Interactions


    Consult your doctor for specific advice if you are taking aminophylline, antacids, cancer drugs, cyclosporine, didanosine, iron supplements, sucralfate, theophylline, or zinc salts.

    Food Interactions


    The effects of caffeine may be magnified by this drug. Milk and dairy products can reduce blood levels of norfloxacin by as much as half.

    Disease Interactions


    Caution is advised when taking norfloxacin. Consult your doctor if you have a disorder of the central nervous system or any other medical condition. Use of norfloxacin may cause complications in patients with kidney disease, since this organ works to remove the medication from the body.

    Serious Side Effects


    Serious reactions to norfloxacin are rare and include seizures, mental confusion, hallucinations, agitation, nightmares, depression, shortness of breath, unusual swelling in the face or extremities, and loss of consciousness. Also skin burning, redness, blisters, rash, or itching on exposure to sunlight. Call your doctor immediately.

    Common Side Effects


    Increased sensitivity to sunlight (and increased risk of sunburn) for days following therapy.

    Less Common Side Effects


    Diarrhea, nausea and vomiting, stomach pain and upset, gas, headache, dizziness, restlessness, insomnia, changes in taste perception, drowsiness, itching, dry mouth, unusual body aches or pains.

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