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Doxazosin Mesylate
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Doxazosin Mesylate In this Article:
Brand Name(s):Cardura Drug Class:Antihypertensive; BPH therapy agent Available OTC?:NoAvailable Generic?:No | |
| |  Cardura 4 mg (Roerig) |
Available InTablets Why PrescribedTo treat mild to moderate high blood pressure; to ease urinary tract symptoms due to benign prostatic hyperplasia (BPH)--that is, noncancerous enlargement of the prostate gland, which is extremely common among men over the age of 50. Note: Findings from a major clinical trial indicate that doxazosin is associated with an unacceptably high incidence of cardiovascular complications. The American Academy of Cardiology has since recommended that physicians reconsider the use of doxazosin in the treatment of their hypertensive patients on a case-by-case basis. How It WorksFor high blood pressure, the drug relaxes and widens blood vessels so blood passes through them more easily. For prostate enlargement, it relaxes muscles in the prostate and the opening of the bladder. Note that doxazosin will not shrink the prostate; symptoms may worsen and surgery may eventually be required. Range and FrequencyFor high blood pressure, initial dose is 1 mg taken once a day. It can be increased gradually to a maximum of 16 mg a day. For prostate enlargement, initial dose is 1 mg taken once a day, which may be gradually increased to a maximum of 12 mg a day. Onset of EffectFor high blood pressure: 1 to 2 hours. For prostate enlargement: 1 to 2 weeks. Duration of ActionFor high blood pressure: 24 hours. For prostate enlargement: Unknown. Dietary AdviceNo special restrictions. StorageStore in a tightly sealed container in a dry place away from heat and direct light. Missed DoseTake it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose. Stopping the DrugTake it as prescribed for the full treatment period, even if you feel better before the scheduled end of therapy. Prolonged UseConsult your doctor about the need for follow-up medical examinations and laboratory studies if you must take doxazosin for a prolonged period. Over 60Adverse reactions may be more likely and more severe in older patients. Dose should be increased slowly in patients over 60. Driving and Hazardous WorkDo not drive or engage in hazardous work until you determine how the medicine affects you. AlcoholAlcohol should be avoided while taking this medicine because it may cause an excessive drop in blood pressure. PregnancyIn animal studies, very high doses of doxazosin damaged the fetus. Before taking this medicine, tell your doctor if you are pregnant or plan to become pregnant. Breast FeedingDoxazosin may pass into breast milk; caution is advised. Consult your doctor for specific advice. Infants and ChildrenThis drug is not recommended for use by children. Special ConcernsThe first dose is likely to cause dizziness or lightheadedness. Take the drug at night and get out of bed slowly the next day. Be cautious while exercising and during hot weather. Tell your doctor whether you will have surgery requiring general anesthesia, including dental surgery, within the next 2 months. Overdose SymptomsCold, sweaty skin, rapid pulse, weakness, loss of consciousness. What to DoCall your doctor, emergency medical services (EMS), or the nearest poison control center immediately. Drug InteractionsConsult your doctor for specific advice if you are taking amphetamines, other antihypertensive drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), estrogen, or sympathomimetic drugs. Food InteractionsNo known food interactions. Disease InteractionsUse of doxazosin may cause complications in patients with liver or kidney disease, since these organs work together to remove the medication from the body. Also, consult your doctor if you have coronary artery disease, impaired blood circulation to the brain, or mental depression. Serious Side EffectsIrregular heartbeat. Call your doctor immediately. Another serious but rare side effect is priapism, a condition characterized by a prolonged or painful erection (lasting more than 4 hours). Common Side EffectsDizziness, drowsiness. Less Common Side EffectsHeadache, weakness, palpitations, rapid pulse, pain and tingling sensations in the fingers or toes, diarrhea or constipation, runny nose, rash or itchy skin, muscle or joint pain, headache, mental depression. | |
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