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Acetohexamide
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Brand Name(s):Dymelor Drug Class:Antidiabetic agent/sulfonylurea Available OTC?:NoAvailable Generic?:Yes | |
| |  Generic 250 mg (Schein) |
Available InTablets Why PrescribedUsed as an adjunct (supplemental) therapy to dietary modification to help control sugar levels in patients with non-insulin-dependent (type 2) diabetes mellitus. How It WorksIt stimulates the pancreas to produce more insulin. Increased insulin levels reduce blood glucose levels and promote the transport of glucose into muscle cells and other tissues, where it is burned for energy. Range and FrequencyStarting at 250 mg once a day, increased as needed to a maximum of 1.5 g per day. In patients receiving less than 1 g per day, sugar levels can usually be controlled with a once-a-day dose; for those receiving between 1 and 1.5 g, the drug is given in two daily doses, morning and evening. Onset of EffectWithin one hour. Duration of Action12 to 24 hours. Dietary AdviceTake it with food or liquid to minimize stomach upset. StorageStore in a tightly sealed container away from heat, moisture, and direct light. Missed DoseIf you miss a dose, take it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and return to your regular schedule. Do not double the next dose. Stopping the DrugDo not stop taking acetohexamide without consulting your doctor. Prolonged UseThe dosage may need to be adjusted with prolonged use. Over time, many patients become resistant to the effects of the medication and may require treatment with insulin instead. Over 60A smaller dosage is usually warranted for older patients. Driving and Hazardous WorkNo problems are expected. AlcoholDrink in moderation only. Small amounts of alcohol at mealtimes usually cause no problems with blood sugar; however, alcohol may cause unpleasant flushing in the face, arms, and neck, up to 12 hours after ingestion. PregnancyAcetohexamide is not usually given during pregnancy. Insulin is generally the treatment of choice for pregnant diabetic patients. Breast FeedingAcetohexamide may pass into breast milk; caution is advised. Consult your doctor if you are considering breast feeding. Infants and ChildrenSafety and effectiveness have not been established for young patients. Special ConcernsFollow your doctor's advice about diet, exercise, and weight control carefully. These aspects of treatment are just as essential to the proper control of diabetes as taking the medication. At all times, be sure to carry some form of medical identification that indicates you have diabetes and that lists all of the drugs you are taking. Overdose SymptomsExcessive hunger, nausea, anxiety, cold sweats, drowsiness, rapid heartbeat, weakness, changes in mental state, loss of consciousness (indications of hypoglycemia). Overdose is most likely to occur after you have delayed or missed a meal, have exercised more than usual, or have consumed more than a small amount of alcohol. What to DoCall your doctor, emergency medical services (EMS), or local hospital immediately. Drug InteractionsThe effects of acetohexamide can be altered by anti- coagulants, antidepressants, aspirin, over-the-counter cold preparations containing aspirin, some diuretics, glucagon, beta-blockers, steroids, phenylbutazone, probenecid, rifampin, nonprescription drugs for colds, hay fever, and appetite control, and sulfa-containing antibiotics. Food InteractionsA special diet is essential for proper control of blood glucose levels. Avoid foods high in sugar. Disease InteractionsLiver disease, over active or under active thyroid, and kidney disease can affect the activity of the drug. Serious Side EffectsHypoglycemia (blood sugar levels that are too low), resulting in shakiness, headache, cold sweats, anxiety, and changes in mental state. Stop taking the drug and seek medical help immediately. Severe diarrhea, bleeding, bruising, chills, fever, stomach pain, or heartburn may also occur; stop taking the drug and notify your doctor. Other serious but less-common side effects include bone marrow suppression, hemolytic anemia, and elevation of liver-associated enzymes; these problems can be detected by your doctor. Common Side EffectsIncreased skin sensitivity to sunlight. Less Common Side EffectsFatigue, itchy skin, sore throat, ringing in ears, weakness. Drug/Nutrient Interactions | |
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